The last three months have been rough for Nektar Therapeutics (NKTR)
and its shareholders, as the company announced significant
manufacturing issues with its key lead drug, as well as a substantially
reduced clinical partnership program with Bristol-Myers (BMY).
On top of all that, there are still valid open questions as to whether
that lead drug (bempegaldesleukin, or “bempeg”) even has a durable
clinical effect.
There are very few sure things in
biotech, and Nektar is no exception. I’m guardedly positive on the
potential of bempeg in melanoma, but cannot rule out the risk that the
ongoing pivotal study results in failure. Likewise with other late-stage
clinical programs like renal cell carcinoma. While Nektar does have
other products in the pipeline, they’re all early-stage and unproven,
with relatively low risk-weighted probabilities of success. I do believe
a risk-weighted approach still suggests Nektar is undervalued, but this
is a high-risk biotech and a lot is riding on incremental clinical
updates between now and the end of the year.
Read the full article here:
Nektar Hammered On Multiple Setbacks; Core Efficacy Questions Remain Open