Roche could really use some meaningful clinical wins now. This was a year of significant clinical read-outs, and thus far Roche doesn't really have any big wins. Not only does that hurt the revenue outlook, but it also saps confidence and sentiment. Valuation isn't really compelling in either direction right now; while I expect many will continue to defend Roche as a long-term buy-and-hold core holding, I think the incoming new CEO may want to think about some internal restructuring with an eye toward generating better long-term returns.
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